公開日 2017年05月19日
第230回 遺伝子機能解析部門セミナー
（第351回 細胞工学研究会講演会）
日時：2017年6月14日（水）16:00-17:15
場所：島根大学生物資源科学部1号館2階203室
演題：The Vertebrate Calcium-Sensing Receptor: Comparative and Evolutionary Approaches to Understanding Its Biological Functions
脊椎動物におけるカルシウム感知受容体の機能：比較進化学的研究から
演者：Christopher A. Loretz 氏（Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York, U.S.A.）
The calcium-sensing receptor (CaSR) is the key detector of calcium concentrations in the blood and extracellular fluids of vertebrates. CaSRs have a deep evolutionary history, deriving from ancestral G protein-coupled receptors (GPCRs) of the pheromone, odorant and vomeronasal receptor family. Among the major vertebrate animal groups, CaSRs exhibit distinct taxon-specific differences in protein sequence and 3D structure. Based on statistical analysis of codon usage, vertebrate CaSRs have experienced strong purifying selection that results in evolutionary conservation of its core protein structure generally. But there is also evidence for bouts of positive, or diversifying, selection along the branches to major vertebrates groups. Since functional activities of CaSRs correspond to specific amino acid sequences and protein motifs, the taxon-specific evolutionary changes may be related to specific features in the life histories of different vertebrate groups. CaSRs are critically important in vertebrate skeletogenesis, and may have played a role in the emergence of vertebrate “bone.” （つづく）
（第351回 細胞工学研究会講演会）
日時：2017年6月14日（水）16:00-17:15
場所：島根大学生物資源科学部1号館2階203室
演題：The Vertebrate Calcium-Sensing Receptor: Comparative and Evolutionary Approaches to Understanding Its Biological Functions
脊椎動物におけるカルシウム感知受容体の機能：比較進化学的研究から
演者：Christopher A. Loretz 氏（Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York, U.S.A.）
The calcium-sensing receptor (CaSR) is the key detector of calcium concentrations in the blood and extracellular fluids of vertebrates. CaSRs have a deep evolutionary history, deriving from ancestral G protein-coupled receptors (GPCRs) of the pheromone, odorant and vomeronasal receptor family. Among the major vertebrate animal groups, CaSRs exhibit distinct taxon-specific differences in protein sequence and 3D structure. Based on statistical analysis of codon usage, vertebrate CaSRs have experienced strong purifying selection that results in evolutionary conservation of its core protein structure generally. But there is also evidence for bouts of positive, or diversifying, selection along the branches to major vertebrates groups. Since functional activities of CaSRs correspond to specific amino acid sequences and protein motifs, the taxon-specific evolutionary changes may be related to specific features in the life histories of different vertebrate groups. CaSRs are critically important in vertebrate skeletogenesis, and may have played a role in the emergence of vertebrate “bone.” （つづく）